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Member since: 2014
Organization: Leibniz Institute of Plant Biochemistry- Molecular Signal Processing
Application Area: Protein Protein Interaction
"iTC200 micro calorimeter (MALVERN) uses minimum volume of samples compared to other old VP-ITC. Easy to handle and support from the company is very good! Binding data is also quite reproducible and reliable. Can be used both for chemical and biological experiments."
The MicroCal iTC200 is a highly sensitive, low volume isothermal titration calorimeter for the label-free in solution study of biomolecular interactions.
It delivers direct measurement of all binding parameters in a single experiment and can analyze weak to high affinity binders, using as little as 10 µg sample. Semi-automated maintenance minimizes operator intervention and the system is upgradable to the fully automated MicroCal Auto-iTC200, making it ideal for laboratories where speed, sensitivity and the ability to accommodate higher workloads in the future are paramount.
The MicroCal iTC200 is designed for ease-of-use and exceptional sensitivity. Its wide affinity range enables analysis of weak to high affinity binders with exceptional reproducibility. Automated cleaning and syringe loading functions minimizes operator involvement while user-friendly software guides all operations for fast, accurate analysis. The system directly measures heat released or absorbed during biochemical binding events, from which it calculates binding affinity (KD), stoichiometry (n), enthalpy (ΔH), and entropy (ΔS). With minimal sample preparation and system optimization data is generated quickly and easily.