MEPS (patent pending) performs the same function as SPE, namely the purification or speciation of samples, but with some significant differences:
MEPS works with much smaller samples (as small as 10µL) than full scale SPE
MEPS can be fully automated – the sample processing, extraction and injection steps are performed on-line using the same syringe
MEPS is applicable to GC and LC
Significantly reduces the volume of solvents and sample needed
Peter Dawes, chairman of SGE Analytical Science, speaks to "The Column" about the benefits & applications of this novel approach. Read more...
To view an animated presentation on MEPS click here.
Sample Size and Sensitivity:
Sample volumes as small as 10µL can be used or larger samples, 1mL or more, may be concentrated by taking multiple aliquots of 100µL or 250µL.
Typical BIN life is conservatively about 40-100 samples but actual life is dependant on the sample matrix. The small quantity of phase in the MEPS BIN can be easily and effectively washed between samples which removes the possibility of carry-over. This process simply is not practical on conventional SPE devices.
Flexible and easy to use:
MEPS BINs are available in a variety of common SPE phases. The dimensions of the sorbent bed ensure that the sorbent performance remains identical to conventional SPE devices used for extraction of similar samples
Sample preparation for complex biological samples is readily adapted to MEPS and reduces the volume of sample and reagents required for extraction when compared with conventional SPE and other "micro extraction procedures".
The MEPS approach to sample preparation is suitable for reversed phases, normal phases, mixed mode and ion exchange chemistries. Because MEPS BINs can be used for sample volumes as small as 10µL it makes them particularly well suited to on-line use with LC-MS analysis of volume limited samples.