iCell® Endothelial Cells, interior surface blood vessel cells derived from human induced pluripotent stem (iPS) cells facilitate vascular-targeted drug discovery, tissue regeneration, and other life science research.
iCell® Endothelial Cells exhibit characteristic endothelial gene and protein expression (e.g., CD31, CD105, CD144, ZO-1, and von Willebrand Factor) and endothelial cell functions (e.g., tubular formation, acetylated LDL uptake, barrier function, and wound healing). These cells are an ideal in vitro model system that provides a reliable source of endothelial cells suitable for use in vascular biology research including angiogenesis, atherosclerosis, inflammation, and many other research areas.
iCell® Endothelial Cells are shipped as cryopreserved suspensions of dissociated cells with medium supplement, specially formulated for optimal cell performance. iCell Endothelial Cells remain viable in culture for up to 5 passages, thus enabling assessment of both acute and longer-term testing.
iCell® Endothelial Cells Benefits:
- Human Cells - Cells are differentiated from human pluripotent stem cells that provide an easily accessible and physiologically relevant model system for vascular-targeted drug discovery, tissue regeneration and other vascular biology research.
- Highly Pure Cell Population - Provides endothelial cell-specific responses to reference molecules.
- Homogenous and Reproducible
- Fully Functional Model - Cells exhibit standard biochemical characteristics of normal human endothelial cells, and demonstrate utility in a variety of assays including cell migration, cytokine stimulation, tubular formation, and impedance/barrier function.
- Easy to Implement - Cells are shipped as cryopreserved suspensions of dissociated cells. Simply thaw and use.
- Acute and Longer-term Testing - Cells remain viable in culture for up to 5 passages, thus enabling assessment of both acute and longer-term testing.
- iPS Cell-derived
iCell® Endothelial Cells Applications:
- Cells are amenable to a wide array of assays including: Cell adhesion, Cell invasion and migration, Cell permeability, Cell proliferation, Cell viability, Impedance/transendothelial electrical resistance, Tubular formation.