ChemBridge has assembled an exemplary collection of small molecules useful for fragment-based screening: the Fragment Library. The emergence and development of high throughput X-ray crystallography an...read more
ChemBridge has assembled an exemplary collection of small molecules useful for fragment-based screening: the Fragment Library. The emergence and development of high throughput X-ray crystallography and NMR methodologies for drug discovery have contributed widely to the acceptance and implementation of fragment-based screening. The ability to detect low affinity binders has proven invaluable in the introduction and promotion of this aspect of drug discovery and design. The Fragment Library was chosen based upon the commonly accepted Astex Rule of Three1 as well as proprietary ChemBridge substructure filters.
Fragment Library Selection
Compounds are selected according to various diversity parameters and Astex Rule of Three considerations (MW ≤ 300, H-bond donors ≤ 3, H-bond acceptors ≤ 3, cLogP ≤ 3). The commonly publicized cLogSw (calculated aqueous solubility) lower limit can be as low as -3.50, however, the -2.50 limit (approx. 3mM) applied by ChemBridge ensures a higher calculated aqueous solubility. Structural diversity of the fragment library has been independently assessed, confirming that the overall selection displays good diversity.
Write a review
Sharing your experience will help scientists like you. Achieve Reviewer Status and Win an iPad air (All reviews published will be entered into the next drawing on May 30th 2014).
Why make an enquiry with SelectScience?
EASY It’s quick and simple to do
FAST Your enquiry will be delivered straight to the manufacturer
FREE You’re under no obligation
SECURE We only pass your details on to trusted suppliers at your request
SAVE TIME Submit your details once and make multiple enquiries