The Corning® CellBIND® surface, the first novel cell culture surface treatment in over 20 years, is designed to improve cell attachment under difficult conditions, such as reduced-serum or serum-free medium, resulting in higher cell yields. It is also useful for growing "difficult" cells such as primary cultures or transfected cells over expressing proteins. Developed by Corning scientists, this patented technology (U.S. Patent 6,617,152) uses a novel microwave plasma process for treating the culture surface. This process improves cell attachment by incorporating significantly more oxygen into the cell culture surface than traditional plasma or corona discharge treatments, rendering it more hydrophilic (wettable) and increasing the stability of the surface.
Unlike biological coatings, the Corning® CellBIND® surface is a nonbiological surface that requires no special handling or storage. Because the polymer is treated, rather than coated, the surface is more consistent and stable. This enhanced cell performance has already led to a major biotechnology company choosing Corning® roller bottles with the Corning® CellBIND® surface for producing a new FDA approved protein therapeutic.