BIOSTAT® CultiBag STR Plus
Innovative Bioreactor, Sensor and Stirrer Technology The BIOSTAT® CultiBag STR Plus is a stirred single use bioreactor available from small scale to large scale cultivation up to 1000L. Its design is entirely based on the conventional gold standards coming from the stainless steel systems, allowing for easy scale-up and transfer from stainless steel solutions. The BIOSTAT® CultiBag STR Plus consists of one BIOSTAT® STR Plus…
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Great result
Tissue sample analysis
It is so easy to use and great capacity and control.
Review Date: 13 May 2024 | Sartorius Group
Great piece of equipment
Seed and production of recombinant protein
Very good product, saves lot of downtime and scare utilities
Review Date: 30 Nov 2015 | Sartorius Group
Innovative Bioreactor, Sensor and Stirrer Technology
The BIOSTAT® CultiBag STR Plus is a stirred single use bioreactor available from small scale to large scale cultivation up to 1000L. Its design is entirely based on the conventional gold standards coming from the stainless steel systems, allowing for easy scale-up and transfer from stainless steel solutions. The BIOSTAT® CultiBag STR Plus consists of one BIOSTAT® STR Plus Control Tower, one bag holder, a single-use CultiBag STR and superior BioPAT® MFCS/DA data logging software. Single as well as twin versions are available.
It is ideal for:
- Cell Culture applications
- Industrial and academic research
- Process development
- Process optimization
- Pilot scale production
- Seed cultivation for large scale bioreactors
- Production scale
Features:
- Completely single use bioreactor in traditional design
- Top driven stirrer with magnetic coupling
- Application driven fully flexible gassing system
- Available as single and twin version
- User-friendly touch screen interface for easy operation
- Single use optical DO & pH sensors for measurement
- Single use bags available with working volumes of 50L, 200L, 500L and 1000L
- Validation & Extractible guide available
Large Scale Cultivation of CHO Cells in the Stirred Single-Use Bioreactor BIOSTAT CultiBag STR
The BIOSTAT CultiBag STR is the only single-use bioreactor which is engineering completely on principles known from reusable bioreactors. It is completely comparable to conventional stainless steel bioreactors and fully scalable. In this study, we have demonstrated the successful batch cultivation of CHO DG44 in serum free, chemically defined media under tight feedback control of pH and DO. Cell densities of 6.3 + 106 cells/mL, which are typical for the particular clone when grown in a bioreactor, could easily be reached while maintaining good viability.
Large Scale Cultivation of CHO Cells in the Stirred Single-use Bioreactor BIOSTATR CultiBag STR
In this application note, Sartorius demonstrate the performance of the BIOSTATR CultiBag STR in the batch mode cultivation of CHO in a culture volume of 200 L. Serum free media was used for the cultivation. The particular CHO clone used for this study is the in house generated DG44 ST1-C6 expressing a human IgG. Typically, it reaches cell densities between 6-7 + 106 cells/mL when grown in bioreactors in this type of media.
Comparison of Single Use Bioreactor BIOSTAT® CultiBag RM and Reusable STR for Cultivation of CHO Cells in Serum Free Media
In this application note, Sartorius present a study of the cultivation of suspension adapted CHO-S and CHO-K1 cells in the single use bioreactor BIOSTAT® CultiBag RM compared to the BIOSTAT® B-DCU® with stirred glass vessels. Serum free chemically defined media was used for the propagation of cells. Growth characteristics and basic metabolic profiles were investigated.
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