In an article referenced in the CAS databases available in SciFinder and on STN, researchers from the Brigham and Women's Hospital in Boston reported their findings on long-term vitamin E or C supplementation and risk of heart attacks and stroke in men:
Taking Vitamin E for Disease Prevention? Which Isomer?
Sesso, H.D.; Burning, J.E.; Christen, W.G.; Kurth, T.; Belanger, C.; MacFadyen, J.; Bubes, V.; Manson, J.E.; Glynn, R.J.; Gaziano, J.M. Vitamin E and C in the Prevention of Cardiovascular Disease in Men
. J. Am. Med. Assoc. 2008, 300(18), 2123-2133.
They found that "neither vitamin E nor vitamin C supplementation reduced the risk of major cardiovascular events" in a group of nearly 15,000 male participants after an average of 8 years of supplementation. Two weeks earlier, the National Cancer Institute announced that preliminary analysis of data from a large human study indicated that vitamin E does not prevent prostate cancer.1 Based on these discouraging findings, why is it important to continue studying vitamin E for disease prevention?
Participants in these studies were given a form of vitamin E known as alpha-tocopherol.2 While there is significant justification for studying alpha-tocopherol, information in the CAS databases suggests that additional forms of vitamin E should be considered for disease prevention. In fact, the term "vitamin E" refers to eight natural isomers: Name:
alpha-tocopherol CAS Registry Number(R):
beta-tocopherol CAS Registry Number(R):
gamma-tocopherol CAS Registry Number(R):
delta-tocopherolCAS Registry Number(R):
alpha-tocotrienol CAS Registry Number(R):
beta-tocotrienol CAS Registry Number(R):
gamma-tocotrienol CAS Registry Number(R):
delta-tocotrienol CAS Registry Number(R):
The following review articles referenced in the CAS databases summarize the literature on gamma-tocopherol, the form of vitamin E most commonly consumed in the typical U.S. diet:
Dietrich, M.; Traber, M.G.; Jacques, P.F.; Cross, C.E.; Hu, Y.; Block, G. Does Gamma-Tocopherol Play a Role in the Primary Prevention of Heart Disease and Cancer? A Review. J. Am. Coll. Nutr. 2006, 25(4), 292-299.
Jiang, Q.; Christen, S.; Shigenaga, M.K.; Ames, B.N. Gamma-Tocopherol, the Major Form of Vitamin E in the US Diet, Deserves More Attention. Am. J. Clin. Nutr. 2001, 74, 714-722.
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