In a first step, nucleic acids are associated with specifically coated magnetic nanoparticles. Exploiting a strong magnetic force, the full nucleic acid dose is then rapidly drawn towards and delivered into the target cells leading to efficient transfection without disturbing the membrane architecture and without causing chromosomal damage.
For a standard Magnet Assisted Transfection the "MATra-A Reagent" is used; for more critical cells it is also possible to combine the MATra technology with lipofection ("Magnet Assisted Lipofection") using our MA Lipofection Enhancer and common transfection reagents. MATra can be used with adherent cells as well as with suspension cells. However, for suspension cells, cells have to be immobilized temporarily using MATra-S Immobilizer. MATra shows an extremely low cytotoxicity, it is functional with serum and serum-free and it is very cost-effective. MATra can also be adapted to high-throughput transfection assays using robotic stations and adapted protocols.