SafeView - Safer Alternative to Ethidium Bromide

15 May 2008
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SafeView is a new, safe nucleic acid stain for the detection of double-stranded DNA, single-stranded DNA and RNA in Agarose gels. This dye replaces Ethidium Bromide (toxic, potential mutagen) commonly used in Agarose gel electrophoresis.

SafeView is as sensitive as Ethidium Bromide and is used in the same way for electrophoresis. SafeView emits green fluorescence when bound to dsDNA and red fluorescence when bound to ssDNA or RNA. This stain has two fluorescence excitation maxima when bound to nucleic acid, at approx. 290nm and 490nm.

SafeView is non-carcinogenic and causes significantly fewer mutations in the Ames-test and tests negative in both the mouse marrow chomophilous erythrocyte micronucleus test and mouse spemary spermatocyte chromosomal aberration test. SafeView can be disposed of as any other non-carcinogenic fluorescent dye (eg Acridine Orange).

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NBS Biologicals Ltd.