The emergence and development of high throughput X-ray crystallography and NMR methodologies for drug discovery have contributed widely to the acceptance and implementation of fragment based screening. The ability to detect low affinity binders has proven invaluable in the introduction and promotion of this aspect of drug discovery and design.
The Fragment Library set, comprising approximately 7,800 compounds, was chosen based upon the commonly accepted Astex "Rule-of-Three" (MW <300, H-bond donors/acceptors <3, cLogP <3) as well as the established proprietary ChemBridge substructure filters. The set includes compounds with available, as well as protected, functionality. All compounds in the collection are available in stock and may be cherry-picked or taken as a complete set.
Upon independent analysis of ChemBridge’s Fragment Library, an industry expert from a well respected pharmaceutical company regards the collection as both attractive and diverse.
"The fragment collection has been assembled using industry standard chemometrics coupled with ChemBridge's knowledge of small molecule pharmacophore profiling,” said ChemBridge’s Reg Richardson, Ph.D. “The result is the largest commercial offering of 'discovery chemistry-relevant' small molecule fragments. I am certain the Fragment Library will be valuable to those engaged in fragment based screening to identify and construct new chemical entities having excellent lead-like properties."