According to data from two presentations at the meeting, Abbott’s PCR/ESI-MS technology may be able to accurately detect hard-to-culture bacteria and identify a diverse array of gram-negative bacterial antibiotic resistance genes. The technology may help guide physicians in the safe and appropriate use of antibiotics. Additionally, the technology combines the high levels of sensitivity and specificity of polymerase chain reaction (PCR) technology with the precision and accuracy of mass spectrometry. This combination is designed to allow for identification and characterization of very broad groups of pathogens without having to narrowly focus on detecting each microbe individually. The result is the ability to cover many more organisms at once.
Abbott is currently developing a test that detects and identifies nearly 800 species of bacteria and candida directly from human blood and identifies genetic markers that predict bacterial drug resistance. Rapid diagnosis of these infections can be crucial for successful patient outcomes.
Using Molecular Diagnostics to Decipher the Genetic Basis of Antibiotic Resistance in Clinical Isolates of Gram-Negative Bacteria:
Detection of Anaerobic Bacteria Directly from Clinical Specimens with PCR followed by Electrospray Ionization Mass Spectrometry (PCR/ESI-MS) vs. Anaerobic Culture: https://idsa.confex.com/idsa/2013/webprogram/Paper39238.html