Deep Clonal Profiling of Purified Tumor Cell Populations From FFPE Clinical Samples
26 Nov 2014
Formalin fixed paraffin embedded (FFPE) tissues are a vast resource of clinically annotated samples. High definition genomics of these informative materials could improve patient management and provide a molecular basis for the selection of personalized therapeutics. A collaboration between several research groups around the world, including the laboratory of Dr. Michael T. Barrett at Translational Genomics Research Institute (TGen), has developed a method based on flow cytometry cell-sorting to isolate individual tumor cell populations from FFPE tissues, as well as methods for their accurate genomic analysis.