Quantitation by High Resolution Mass Spectrometry: Using Target Enhancement and Tof-MRM to Achieve Femtogram-level On-column Sensitivity for Quantitation of Drugs in Human Plasma
9 Oct 2014

In this application note the SYNAPT G2-S instrument is used to determine and compare the quantification attributes of detection limit (LOD), quantification limit (LOQ), and linear dynamic range for three data-acquisition modes: full-scan MS, MSE and Tof-MRM. In the presence of human plasma, the Tof-MRM mode of data acquisition can achieve on-column limits of detection that are in the low-femtogram range. Tof-MRM has direct applicability for bioanalysis, targeted metabolism, stability, and PK/PD profiling studies with low detection limits.

Show    per page
2 of 21     Page  1 2 3  ... Next 
Collision Cross Section: A New Identification Point for a “Catch All” Non-Targeted Screening Approach pesticides, food safety, food testing29 Sep 2014Read
Detecting a New Wave of K2/Spice in Human Urine cannabinoids, human urine26 Sep 2014Read
Quantitative LC-MS Screening for Illicit Drugs Using Ultrahigh Resolution Mass Analysis and Accurate Mass Confirmation urine analysis, drugs of abuse, drug testing26 Sep 2014Read
Mass-Directed Isolation of Sulfa Compounds from an Antibiotic Mixture with an ACQUITY QDa Detector antibiotics25 Sep 2014Read
Analyzing Multi-Class Persistent Organic Pollutants (OCPs, PCBs, PBDEs, and PAHs) in Food Matrices in a Single Injection by APGC-MS/MS food safety, food testing, food contamination25 Sep 2014Read
Screening of 300 Drugs in Blood Utilizing Second Generation Exactive Plus High-Resolution, Accurate Mass Spectrometer and ExactFinder Software Mass Spectrometry, blood analysis, forensic toxicology24 Sep 2014Read
Utilizing a Hybrid Mass Spectrometer to Enable Fundamental Protein Characterization: Intact Mass Analysis and Top-Down Fragmentation with the LTQ Orbitrap MS protein analysis, Mass Spectrometry, electrospray ionization24 Sep 2014Read
The Determination of Toxic, Essential, and Nutritional Elements in Food Matrices Using the NexION 300/350 ICP-MS food testing, food contamination23 Sep 2014Read
Purge&Trap Extraction of Volatiles in Drinking Water and High Speed TOF MS Detection in Compliance to EPA 524.3 drinking water analysis, VOC monitoring, EPA methods22 Sep 2014Read
A Method for the Rapid and Simultaneous Analysis of Sweeteners in Various Food Products Using the ACQUITY H-Class System and ACQUITY QDa Detector artificial sweeteners, food testing, sugarcane22 Sep 2014Read

Popular tags in SelectScience