Figure Out Aggregation Early: Simultaneous, Independent Measurements of B22 and kD on UNcle
28 April 2017

This application note describes how UNcle can be used to predict the aggregation propensity of proteins. UNcle can analyse up to 48 samples simultaneously and measure both Dynamic Light Scattering (DLS) and Static Light Scattering (SLS) to obtain the B22 and kD parameters, well-established predictors of colloidal stability and aggregation propensity, efficiently with minimal amounts of protein. UNcle thus provides an easy and quick tool for selecting winning constructs or formulations that reduce protein aggregation risk.