High-Throughput LC/MS MRM Disease Protein Marker Verification Using the ionKey/MS System
31 August 2015
This application note describes a novel microfluidics platform for the quantification of marker peptides and proteins, considering speed, sensitivity, and selectivity. Biomarker discovery and validation are the first two steps in understanding disease and drug development. Validation is technology-challenged since it requires analyzing a large number of samples with high-throughput, but nevertheless requires high sensitivity, high resolution, large dynamic range and excellent selectivity.