Drug Screening and siRNA Transfection Using a “DropChip” Cell Array
8 September 2017

In this application note, a “DropChip” microarray has been developed for multiplexed cell-based assays in order to perform information-rich high-throughput screening. With the arrayed cell culture nanoliter droplets, synergic effects of siRNA and cisplatin were analyzed. With up to 100 cells per drop, cell behavior at the individual cell level could be analyzed, using high resolution fluorescence microscopy and automated image analysis. This novel cell array format could enable highly informative functional genomic studies and large scale in vitro toxicity testing.