Application Note: Phenotypic and Epigenetic Mechanism of Action Determinations of Histone Methylase and Demethylase Inhibitors Using Digital Widefield Microscopy
4 Mar 2015

This poster demonstrates monitoring of the effect of histone methylase and demethylase inhibitors that selectively induce apoptosis in cancer cell lines. Induction of apoptosis was monitored using fluorescent probes, while the photoproteins allowed differentiation of the final cytotoxic effect on the two cell types in the co-culture. All assessments were made via digital microscopy using the Cytation™ 5 cell imaging multi-mode reader.