SMi is launching its inaugural Immunogenicity Conference, taking place in London on the 14th and 15th July. This two day event is designed to enhance SMi’s portfolio of pharmaceutical conferences, especially with a growing demand for biologic therapeutics.

We ask the questions: What stimulates an immune response? How does the system cope with immunogenic compounds? And how do you screen for potential problems?

The Conference will address all these concerns and enable Clinical Immunologists, Physicians and Specialists within the field of Immunogenicity to discuss the major challenges currently being faced within the pharmaceutical industry.

The focus is on pre-clinical analysis and assessing treatments for clinical development. It will endeavour to look at the assessment of early risks in immunogenicity and the evaluation of in silico tools for determining immunogenicity. With an insight into the safety, development and validation of Monoclonal Antibodies.

Immunogenicity is a hurdle one looks to overcome and with the likes of aggregation being a factor when handling proteins, key sessions on Immunomodulation and Inducing Immunological Tolerance will enable delegates to get an understanding of how to address this and improve probability and efficacy.

From a clinical perspective, the conference will assess consideration and design of biologic therapeutics, clinical implications and review what the clinical outcomes are from using these immune modulatory approaches.

The conference will also look at, how to benefit the patient by assessing efficacy and toxicological concerns alongside the management of immunogenic responses. With regulators supposing that animal studies are not good predictors – how can predictability be shown with pre-clinical in-vitro tools?

Business Benefits:
•Grasp an understanding of Immunogenicity and gain an insight into assessing early risks
•Hear case studies on the tools for consideration being utilised for the determination of immunogenicity
•Assess major hurdles in clinical development and the implications in design of biologic therapeutics
•Enhance your understanding on how to best evaluate read outs for immune response
Conference Chairs:
•Matthew Baker, Chief Scientific Officer, Antitope
•Martin Lechmann,Development DMPK Project Leader, Roche
Key Speakers include:
•Robert Dodge, Associate Director, BMS
•Thomas Lee, Scientific Investigator, Clinical Immunology, GSK
•Ronit Mazor, Research Fellow, National Cancer Institute,National Institutes of Health
•Anne De Groot, CEO/CSO, EpiVax Inc
•Daniel Kramer, Associate Director, Project Representative NBE, Merck Serono
•Takashi Kei Kishimoto, Chief Scientific Officer, Selecta Biosciences Inc.

A: Clinical Impact of Immunogenicity and Predictive Tools, Workshop Leader: Melody Sauerborn, Senior Expert Immunogenicity, TNO Triskelion
B: Immunogenicity of Biosimilars, Workshop Leader: John Chappell, Head of Immunoassay, CPR Pharma Services

For more information click on the event website link or contact Fateja Begum on +44 (0) 20 7827 6184 or email

Holiday Inn Regents Park

Organizer: SMi Group Ltd

14 Jul 2014

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