2. Application Articles
  3. Drug Discovery & Development
  4. Combinatorial Chemistry

Therapeutic Peptide Catabolite Identification using MetabolitePilot™ 2.0 Software and the TripleTOF® 6600 System
21 July 2017

Even though the principles of pharmacokinetics and metabolism of small molecule drugs apply to peptide and protein drugs, the mechanisms of metabolism are very different. Small molecule drug metabolism occurs via the conversion of the molecule or moieties into more hydrophilic species via Phase I and Phase II processes.  In this tech note the in-vitro metabolism of a model therapeutic peptide Bivalirudin was investigated to highlight the new peptide catabolism workflow features of MetabolitePilot 2.0 software.  

SCIEX

Download this Article

     Page  1 Next 
Using Stable Isotopes to Solve Problems in Combinatorial Chemistry19 Jul 2017
LVP Application Performance of Millipore Express SHC and SHF 0.2 µm Membranes25 Apr 2017
Comparison of nanoDSF and µDSC for Thermal Stability Assessment during Biopharmaceutical Formulation Development15 Feb 2017
Use of iFormulate™ and nanoDSF for Fast and Precise Protein Formulation Development12 Feb 2017
Transcreener® ADP2 TR-FRET Red Assay: Homogeneous ADP Detection20 Jun 2016
Technical White Paper: SOMAmer® Reagent Specificity4 May 2016