Rapid, Reliable Metabolite Ratio Evaluation for MIST Assessments in Drug Discovery and Preclinical Studies

12 Dec 2012

To comply with U.S. FDA guidelines regarding the safety of drug metabolites in human plasma, there is a need to rapidly evaluate and accurately quantify multiple, diverse drug candidates and metabolites in a discovery or preclinical setting. Methodologies that are generic, fast, and robust are featured in this application note from Waters using Ostro 96-well plates and XBridge BEH XP 2.5 µm columns for accurate metabolite ratio determination.

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