A Novel Dried Matrix Microsampling Device that Eliminates the Volume Based Hematocrit Bias Associated with DBS Sub-punch Workflows
21 Nov 2014
Dried blood spots (DBS) have gained attention as a microsampling tool in modern drug development due to the small blood volumes required, simplicity, low cost, and ease of transport. In order to overcome the volumetric assay bias found in a typical DBS workflow, Merck Millipore has developed a novel microsampling technology that is designed to allow for precise volumetric absorptive microsampling (or VAMS™). This application note illustrates the use of the tool in the collection and analysis of blood samples collected for bioanalysis in drug research following the approach of drying the samples and extracting them in a fashion similar to current practice with DBS cards.