TDA of Insulin Self-Association and Stability under Varying Formulation Conditions using Malvern’s Viscosizer TD
3 August 2015
Taylor Dispersion Analysis (TDA) is an orthogonal technique for sizing and stability studies of biomolecules in solution. Studies have shown that hydrodynamic radius (Rh) measurements from TDA on monodisperse systems such as monoclonal antibodies (mAbs), are comparable to data obtained using the well-established and complementary technique of Dynamic Light Scattering (DLS). In this study, Taylor Dispersion Analysis (TDA) has been employed using Malvern Instrument’s Viscosizer to assess the oligomeric state and stability of Insulin under varying buffer and excipient conditions.