Accelerating Biotherapeutic Process Development Using Differential Scanning Calorimetry
13 June 2016
This application note focuses on the utility of differential scanning calorimetry (DSC) to inform multiple aspects of the biotherapeutic development processes of IgG and IgE. DSC enables the study of protein unfolding rapidly and with out the use of labelling or artificial probes. The technique determines the heat absorbed by the sample as the protein unfolds, giving a measure of its thermostability and an indication of long-term stability.