Application Note: Using the LCMS-IT-TOF for Indentification of Impurities in Pharmaceutical Candidates Using High Mass Accuracy and MSn Analysis
22 March 2011

In this application note learn how to use a novel hybrid instrument platform to deliver high mass accuracy data and MSn analysis in identifying impurity products from a relatively impure pharmaceutical candidate. Using mass information and pattern matching with MS/MS spectra of pharmaceutical drug candidate, the structure of all suspected impurities in Erythromycin A oxime has been elucidated.