4.5 Minute Analysis of Benzodiazepines in Urine and Whole Blood Using LC-MS/MS and an Ultra Biphenyl Column

13 Aug 2012

Read this application note to learn about a fast dilute-and-shoot LC-MS/MS chromatographic method for therapeutic levels of a comprehensive list of benzodiazepines in urine and whole blood. The analysis shown here by Restek is complete in 4.5 minutes, allowing more samples to be run per shift.

Ultra Biphenyl Columns

Restek Corp.

Properties: Increased retention for dipolar, unsaturated, or conjugated solutes. Enhanced selectivity when used with methanolic mobile phase. Ideal for increasing sensitivity and selectivity in LC-MS analyses particle size: 3 μm or 5 μm, spherical pore size: 100 Å carbon load: 15% endcap: fully endcapped pH range: 2.5 to 8 temperature limit: 80 °C USP phase: L11 phase category: phenyl ligand type: unique Biphenyl

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4.5 Minute Analysis of Benzodiazepines in Urine and Whole Blood Using LC-MS/MS and an Ultra Biphenyl Column