Application Note: Modernization of a HILIC USP Impurity Method for Cetirizine Hydrochloride Tablets
24 January 2017

Most commonly used USP HPLC methods were developed using older columns technologies and contain 5µM particles, however more modern column technologies have been used to update USP methods. In this application note organic impurities in cetirizine hydrochloride tablets are analysed using older USP HPLC methods and using newer USP HILIC methods for comparison. The results in this article show that using newer USP HILIC methods can yield better results in less time.

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