A Guide to Scale-up of Batch Crystallization from Lab to Plant
5 December 2012
Crystallization is a critical processing step in the manufacture of many fine chemical and pharmaceutical products. It can serve simultaneously as a purification step and as a separations unit operation. The design of a robust crystallization process can assure the isolation of a product in the desired size, shape and form required. Real-time monitoring of crystallization is shown to provide many benefits leading to improved methods for process development, optimization and scale-up. This white paper from Mettler Toledo reviews case studies examining many of these benefits, including the use of Process Analytical Technology.