Application Note: Measurement of the Tg' in Formulations
19 June 2012

In designed formulations for lyophilized drugs, it is important to know the collapse temperature of the cake. The collapse temperature is often associated with the Tg’ of the frozen material and measuring this transition is the best way to approximate it. In addition, it is useful to know the amount of non-frozen water, which can be estimated as the enthalpy of melting (ΔH). Both of these necessary values are shown to be obtained with PerkinElmer’s Diamond DSC.