Application Note: Understanding the Colloidal Stability of Protein Therapeutics Using Dynamic Light Scattering
30 July 2014

The combination of dynamic light scattering (DLS) with Raman spectroscopy provides the ability to extract a wealth of chemical, structural, and physical information about biotherapeutic proteins under formulation conditions. This white paper describes the unique ability of DLS, when combined with noninvasive backscatter detector (NIBS) technology, to derive the bulk viscosity/restricted diffusion interaction parameter (kD), particle interaction parameter (B22), melting temperature, onset temperature of aggregation and transition enthalpies on high concentration formulations.