Application Note: A 3D Co-Culture Model-Based Assay to Assess Liver Kupffer-Cell Activation and Functionality
27 March 2013

At the SOT conference in San Antonio Pfizer’s Drug Safety R&D department and InSphero presented poster presentation with results that highlight the potential of our 3D InSight™ Rat Liver Microtissues for evaluating Kupffer-cell mediated liver toxicity. A unique advantage of this model is the ability to do histological assessment of the microtissues to assess pathological changes (which is a sensitive visual end-point for assessing drug induced liver injury).