Application Note: Multiple Flow Cytometric Approaches for Studying DNA Damage Pathways and Assessing the Level of the Cellular Responses to DNA Damage
7 May 2013
Investigation of DNA damage pathways and assessment of the DNA damage levels in cells are extremely important for the study of cancer and developing anti-cancer drugs, as defects in DNA damage pathways can cause cancer and lead to genetic instability and ultimately uncontrolled cell growth. In this scientific poster several assays were successfully used in the evaluation of DNA damaging and anti-neoplastic agents. Their impact on the cell cycle was assessed, which helped elucidate the mechanisms of cell proliferation, apoptosis, and DNA repair, ultimately advancing the study for cancer research.