Direct Detection of Glutathione Conjugates in Human Liver Microsomes Using ACQUITY UPLC I-Class, Xevo G2-S QTof, and UNIFI
26 Mar 2014This application note demonstrates the use of MSE data acquisition for detecting reactive metabolites using clozapine as a model compound. Through integrated charge state deconvolution and detection using the Metabolite Identification Application Solution in UNIFI, all metabolites, including parent, phase I metabolites, and phase II GSH conjugates are detected and tracked across the dataset automatically.
Related Products
Request Quote for All Products
ACQUITY UPLC® I-Class PLUS System
WatersThe most powerful solution to the most critical need in separation science today.
Metabolite Identification Application Solution with UNIFI
WatersThe Waters Metabolite Identification and Application Solution with UNIFI® is built to excel in identifying and characterizing metabolites, incorporating both qualitative and quantitative tools in both drug discovery and development.The UNIFI Scientific Information System brings ease and efficiency to routine processes to enable laboratories to rapidly derive results from complex data sets. In discovery, the system helps researchers acquire answers and knowledge and more quickly so the right molecules can be selected for the pipeline, allowing laboratories to proceed or change direction with confidence. In development, it excels in unsurpassed tracking of metabolites and storage of all data surrounding the study; include pdf and Microsoft Office documents, weblinks, structures, metadata, etc., in its user-manageable scientific library.Solution consists of:ACQUITY UPLC I-Class SystemXevo G2-S QTofUNIFI Scientific Information SystemWaters Analytical Standards and Reagents