Application Note: Determination of Succinic, Glutaric, and Adipic Acids as Quality Control of Cyclohexanone Production
16 May 2012

This work describes an LC-MS method for the determination of succinic, glutaric, and adipic acids in the by-products of cyclohexanone production. Baseline separation of these three aliphatic dicarboxylic acids is observed with resolutions (Rs) ≥ 2.6 and completed within 10 min. Analytes are detected by electrospray ionization (ESI) mass detector operated in the negative ion mode by full scan MS.