Detection and Quantification of Formaldehyde by Derivatization with Pentafluorobenzylhydroxyl Amine in Pharmaceutical Excipients
13 Jul 2012

This application note presents a simple and effective method for the determination of formaldehyde in pharmaceutical excipients using SHS-GC/MS. This is a fast and reliable method that can be used for the quantification of low-molecular-weight aldehydes in most excipients commonly used in pharmaceutical products. Excellent quantification and linear instrument response was reported across a 1 to 50 ppb concentration range of formaldehyde.

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