Application Note: Identification and Comparison of BRCA1 and BRCA2 Variants
8 May 2013

Combined use of Mutiplicom’s BRCA MASTR assay with Ion Torrent’s sequencing technology and data analysis using CLC Genomics Workbench results in high sensitive and specific detection and annotation of cancer relevant mutations in BRCA1 and BRCA2. This application note shows how to analyze amplicon sequencing data and identify cancer relevant variants in these two highly-studied tumor-suppressor genes using CLC Genomics Workbench.