Automation of a Homogeneous Proximity Assay for Immunogenicity Testing of Biological Drug Products
12 Oct 2012

Anti-drug antibodies (ADA) are known to be frequently generated during administration of humanized monoclonal antibody therapeutics. These ADAs are nearly indistinguishable from antibody drug therapeutics thus robust selective methods are required to determine the extent to which they impact safety and efficacy during treatment. This application note compares the automation of an AlphaLISA® ADA activity with a solution ELISA ADA using liquid handling and dispensing instrumentation and a high-throughput screening (HTS) multi-mode reader, the Synergy™ Neo from BioTek, which can be used to detect the presence of ADA activity in a model system.

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