Application Note: Assessment of HDAC1 Inhibition Using an Automated, Bioluminescent Histone Deacetylase I/II Assay
28 March 2013

This application note demonstrates the capacity of a bioluminescent HDAC class I/II assay to be used in a biochemical format to rapidly screen compounds for their ability to inhibit HDAC1 enzyme activity. Results confirm the automated cellular assay’s ability to accurately detect the target-specific inhibitory characteristics of test compounds, with a low false positive rate, in a simple, yet robust manner for these important epigenetic targets.

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