Cell-Based Screening of Focused Bioactive Compound Libraries: Assessing Small Molecule Modulators of the Canonical Wnt Signaling and Autophagy-Lysosome Pathways
2 May 2013

Wnt signaling has been extensively investigated as an effector of diverse physiological processes including neuronal development and plasticity, bone development and formation, as well as pathological diseases, such as cancer and neurodegeneration. In this application note the Screen-Well® Autophagy compound library was screened using the Leading Light™ Wnt Reporter Assay Kit. Sets of Wnt agonists and antagonists were identified among the compounds. Most of the Wnt antagonists identified by this screen are known to be positive modulators of autophagy pathway or mitochondrial poisons.

Popular tags in SelectScience

Buying guides

Write a Review

Join the Global SelectScience Community Today! It’s FREE!

Helping you make informed decisions about the latest lab products and technologies:

  • Be the first to learn about new technologies
  • 10,000+ trusted product reviews from your peers
  • Compare 500,000 products and manufacturers
  • Get exclusive buying tips from experts
  • Find solutions fast: 10,000+ Application Notes, Webinars and Videos

Connect with 250,000 scientists... All in one place!

Become a member today!