Application Note: A Versatile GHB Method for Headspace or Liquid Injection
28 June 2012

System contamination is a significant issue for labs analyzing gamma-hydroxybutyrate (GHB) as typical methods include derivatization and liquid injection. Here, an acid conversion solvent extraction method is evaluated for compatibility with both headspace and liquid injection techniques. This extraction method can improve lab efficiency and reduce contamination by eliminating the use of derivatization reagents.