OneSeq Target Enrichment: Simultaneous Detection of Genome-Wide Copy Number Changes, cnLOH, indels, and Gene Mutations
28 April 2015

This application note introduces OneSeq, a revolutionary all‑in‑one SureSelect target enrichment assay and accompanying SureCall analysis software that detects genome-wide copy number changes, copy neutral loss of heterozygosity (cnLOH), indels, and gene mutations in one comprehensive assay. Samples with known chromosomal aberrations were analyzed and showed that copy number changes from as small as 150 kb to whole chromosome triploidy, stretches of cnLOH, indels, and single base pair mutations, can be detected.