Application Note: Mobile-Phase Cleanup Using Solid-Phase Extraction Disks
17 June 2011

In this comprehensive application note from 3M the authors describe a fast, simple procedure for purifying HPLC mobile phase using solid-phase extraction disks during the filtration step for mobile-phase preparation. The procedure tested was found to remove more than 95% of contaminants, and has been suggested as an effective and suitable solution for various gradient HPLC methods.