Application Note: Ultra-Sensitive Host Cell Protein Detection using CESI-MS with SWATH® Acquisition
17 July 2017

This application note demonstrates the use of CESI-MS with SWATH acquisition for the ultrasensitive detection of host cell proteins (HCPs) in a representative mAb preparation. Highlighting that this system can be used for detection of host cell proteins from limited sample quantities in the early development phase. HCPs were quantified down to the low ppm range and in some cases even into the sub-ppm range, representing detection of HCPs over three orders of magnitude.