Application Note: Rapid Hit Confirmation and Early hERG Liability Testing Using the IonWorks HT System
15 July 2011

This application note illustrates how the IonWorks HT System can be used to rapidly confirm hits from higher-throughput assays as well as perform early hERG liability testing for ion channel targets. Twenty two compounds from Library of Pharmacologically Active Compounds were identified with apparent inhibitory activity on the cardiac sodium channel (Nav1.5) using the FLIPR® Membrane Potential Assay Kit. These 22 compounds were then assayed at a single dose using the IonWorks® HT System and one compound (rimcazole) was confirmed as having inhibitory activity on the Nav1.5 channel.

Download PDF >>PDF Icon

Read the full article...

  Become a member
  • Quick and complete access to all application articles

  • Download 10,000+
    applications and methods

  • Make informed buying decisions

Already a member?

Log in for full access to the article

Remember me