InCELL Hunter: A Novel Cellular Assay Platform for the Direct Measurement of Compound Binding to Epigenetic and Kinase Targets in Intact Mammalian Cells
24 Sep 2012

This poster, presented at ELRIG Drug Discovery 2012, describes how the InCell Hunter™ platform from DiscoveRx Corporation can be used to detect the binding of a small molecule to a protein target of interest in intact mammalian calls by monitoring changes in protein structure and stability. The system has been used to develop a large panel of cell-based kinase, bromodomain and methyl transferase assays for screening and profiling. The InCell Hunter™ platform has the potential to enable the development of cell-based assays for difficult kinase targets including low turnover enzymes and targets whose substrates have not yet been identified.

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