Application Note: GX-271 Oligo Purification System: Streamlined Purification of Assay-Ready Oligonucleotides by Automated HPLC
9 March 2017

Efficient purification of oligonucleotides, of different lengths and at different production scales, presents a manufacturing challenge. The GX‑271 Oligo Purification System, configured with automated preparative and analytical HPLC capabilities, can be used to isolate, analyze, and desalt reagent‑grade oligonucleotides in one continuous run. On‑board fraction analysis during runs enables on‑the‑fly sample addition resulting in no downtime on the instrument.