Application Note: Get the Whole Story: Combine Tm and Tagg with Sizing and Polydispersity on UNcle
7 January 2018

This application note describes how you can use UNcle to get even more information out of a simple Tm and Tagg screen, by opting to collect DLS data at the beginning and end of a thermal ramp. Without adding any more sample volume or set up time to your workflow, get high-resolution information about the size and polydispersity of your samples from the same instrument. Learn about any red flags with your formulations or unstable constructs, and use the sizing information as an additional clarification for samples that display odd behaviors in the thermal ramp measurements.