Cultivation of PER.C6R Cells in the Single Use Bioreactor BIOSTATR CultiBag RM for the Production of Monoclonal anti-EpCAM Antibodies

In this application note, Sartorius report the successful cultivation of PER.C6R in the single-use bioreactor BIOSTATR CultiBag RM. Chemically defined, serum-free media is used for the purpose of producing a high titer of monoclonal antibody in batch and simple fed-batch regime. The growth of the PER.C6R cells in the CultiBag RM was compared to growth in single use shaker flasks.