Robustness of an Agilent 6470 Triple Quadrupole Mass Spectrometer for Analysis of Pharmaceuticals in Plasma Matrices
18 August 2015

This application note demonstrates the advantages of using an Agilent 6470 Triple Quadrupole Mass Spectrometer coupled to an Agilent RapidFire 365 High-throughput MS (HTMS) System for the rapid and robust analysis of pharmaceuticals in plasma. The most common analytical approach for the in vivo identification and quantification of metabolites is to use triple quadrupole mass spectrometers in multiple reaction monitoring (MRM) mode.  However, the analytical performance of these systems can degrade over time as nonvolatile sample matrix components accumulate in the ion source and ion transfer optics. As a result, frequent cleaning may be required to maintain optimal performance. Agilent 6470 Triple Quadrupole Mass Spectrometry (MS) systems feature several key design innovations for sensitive, precise, and robust quantification of target analytes in heavy sample matrices over a wide linear dynamic range.