Increasing the Activity of Monoclonal Antibody Isoforms by MCSGP with the KNAUER Contichrom®
3 Nov 2014
This application note describes how the specific activity of pharmaceutical monoclonal antibodies can be increased by separating more active isoforms from less active isoforms using Multi-column countercurrent solvent gradient purification (MCSGP). The KNAUER Contichrom® system which is offered in a cooperation of KNAUER and ChromaCon is the only system on the market that can be used in MCSGP mode for difficult bio-separations. MCSGP is a countercurrent chromatographic process that is particularly suited for applications in the field of bioseparations.