Total Organic Carbon Determination According to USP 643
21 July 2016

This application note describes the determination of impurities in purified water and water for injections according to the US Pharmacopeia Total Organic Carbon (TOC) parameter. Shimadzu offers two systems that are ideally suitable for TOC determination in ultrapure water. Both types of instrument with their different oxidation methods can be used for TOC determination in accordance with the new United States Pharmacopeia USP 643.